Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility
Identifieur interne : 000D12 ( Main/Exploration ); précédent : 000D11; suivant : 000D13Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility
Auteurs : Wentao Li [Pays-Bas] ; Ruben J. G. Hulswit [Pays-Bas] ; Scott P. Kenney ; Ivy Widjaja [Pays-Bas] ; Kwonil Jung ; Moyasar A. Alhamo ; Brenda Van Dieren [Pays-Bas] ; Frank J. M. Van Kuppeveld [Pays-Bas] ; Linda J. Saif ; Berend-Jan Bosch [Pays-Bas]Source :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2018.
Abstract
Coronaviruses exhibit a propensity for interspecies transmission, with SARS- and MERS-coronaviruses as notable examples. Cross-species transmission by coronaviruses is foremost determined by the virus’ ability to bind receptors of new hosts. We here report that the recently identified, yet globally distributed porcine deltacoronavirus employs host aminopeptidase N (APN) as an entry receptor via S protein-mediated interaction with an interspecies conserved domain that allows for APN orthologue-mediated entry. Identification of APN as a deltacoronavirus receptor emphasizes the remarkable preferential employment of cell surface host peptidases as receptors by coronaviruses. Our findings provide important insight into how receptor usage of coronaviruses may fuel cross-host transmission between distantly related species and necessitate surveillance studies of deltacoronaviruses in thus far unappreciated potential reservoirs, including humans.
Url:
DOI: 10.1073/pnas.1802879115
PubMed: 29760102
PubMed Central: 5984533
Affiliations:
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Van Kuppeveld</name><affiliation wicri:level="1"><nlm:aff id="aff1">Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine,<institution>Utrecht University</institution>, 3584 CL Utrecht,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Saif, Linda J" sort="Saif, Linda J" uniqKey="Saif L" first="Linda J." last="Saif">Linda J. Saif</name><affiliation><nlm:aff id="aff2">Department of Veterinary Preventive Medicine, Food Animal Health Research Program, Ohio Agricultural Research and Development Center,<institution>The Ohio State University</institution>, Wooster,<addr-line>OH</addr-line> 44691</nlm:aff></affiliation></author><author><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name><affiliation wicri:level="1"><nlm:aff id="aff1">Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine,<institution>Utrecht University</institution>, 3584 CL Utrecht,<country>The Netherlands</country>;</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>Coronaviruses exhibit a propensity for interspecies transmission, with SARS- and MERS-coronaviruses as notable examples. Cross-species transmission by coronaviruses is foremost determined by the virus’ ability to bind receptors of new hosts. We here report that the recently identified, yet globally distributed porcine deltacoronavirus employs host aminopeptidase N (APN) as an entry receptor via S protein-mediated interaction with an interspecies conserved domain that allows for APN orthologue-mediated entry. Identification of APN as a deltacoronavirus receptor emphasizes the remarkable preferential employment of cell surface host peptidases as receptors by coronaviruses. Our findings provide important insight into how receptor usage of coronaviruses may fuel cross-host transmission between distantly related species and necessitate surveillance studies of deltacoronaviruses in thus far unappreciated potential reservoirs, including humans.</p></div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Alhamo, Moyasar A" sort="Alhamo, Moyasar A" uniqKey="Alhamo M" first="Moyasar A." last="Alhamo">Moyasar A. Alhamo</name><name sortKey="Jung, Kwonil" sort="Jung, Kwonil" uniqKey="Jung K" first="Kwonil" last="Jung">Kwonil Jung</name><name sortKey="Kenney, Scott P" sort="Kenney, Scott P" uniqKey="Kenney S" first="Scott P." last="Kenney">Scott P. Kenney</name><name sortKey="Saif, Linda J" sort="Saif, Linda J" uniqKey="Saif L" first="Linda J." last="Saif">Linda J. Saif</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Li, Wentao" sort="Li, Wentao" uniqKey="Li W" first="Wentao" last="Li">Wentao Li</name></noRegion><name sortKey="Bosch, Berend Jan" sort="Bosch, Berend Jan" uniqKey="Bosch B" first="Berend-Jan" last="Bosch">Berend-Jan Bosch</name><name sortKey="Hulswit, Ruben J G" sort="Hulswit, Ruben J G" uniqKey="Hulswit R" first="Ruben J. G." last="Hulswit">Ruben J. G. Hulswit</name><name sortKey="Van Dieren, Brenda" sort="Van Dieren, Brenda" uniqKey="Van Dieren B" first="Brenda" last="Van Dieren">Brenda Van Dieren</name><name sortKey="Van Kuppeveld, Frank J M" sort="Van Kuppeveld, Frank J M" uniqKey="Van Kuppeveld F" first="Frank J. M." last="Van Kuppeveld">Frank J. M. Van Kuppeveld</name><name sortKey="Widjaja, Ivy" sort="Widjaja, Ivy" uniqKey="Widjaja I" first="Ivy" last="Widjaja">Ivy Widjaja</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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